During a engagement to Lichfield Cathedral on the start of the week, the King was heckled by a individual who asked him about Prince Andrew's links with disgraced financier Epstein.
The man inquired how long the King had been aware about his brother's association with Jeffrey Epstein, and also questioned whether he had asked the police to "conceal" for Prince Andrew.
Amid the protest, there were throngs of supporters and applause for the monarch, who was in Staffordshire for an event.
Prince Andrew's links with Epstein have been under renewed focus in the past few weeks. The prince, who relinquished his royal duties earlier this month, has strongly denied any wrongdoing.
"For how long have you known about Prince Andrew and Epstein? Have you asked the police to cover up for him?"
The monarch ignored the questions but continued greeting fans, some of whom shouted "God Save The King". One fan can be overheard asking him for a hug.
Another woman outside the cathedral was also heard telling the heckler to "go away" and to "be quiet".
The controversy over the Duke of York's links to Epstein has been brought back into focus by misconduct allegations detailed in Virginia Giuffre's recently released book.
In the publication, the accuser says she had sex with the royal on multiple times, including one instance with Jeffrey Epstein and "eight other young girls"
Andrew, who reached a financial settlement with Ms Giuffre in recent years, has consistently denied any misconduct. In a previous interview, he told a news program he did not remember meeting Ms Giuffre "at all", and that they "did not have any sort of sexual contact."
But recently, fresh questions have been raised about how he is able to fund his way of life despite not being a working royal.
The disclosure that he has only ever paid a nominal fee on his Windsor mansion has intensified the examination over his housing situation - even though he made significant contributions initially, including for renovations.
The Liberal Democrats said he should be summoned before members of parliament to give evidence about his lease of his lodge.
But last Thursday, the government refused to give parliamentarians time to debate the royal's titles or his residence, despite increasing calls for scrutiny.
Buckingham Palace has not issued a statement on whether the Duke of York might move out of his home - or where he might reside.
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